To transcribe or to splice: SKIP-mediated development and environmental fitness in Arabidopsis
报告题目：To transcribe or to splice: SKIP-mediated development and environmental fitness in Arabidopsis
系列：“生态与环境讲坛”系列第 183 讲
摘要：SKIP is an evolutionarily conserved protein from yeast to humans. In plants, We verified that SKIP is a bifunctional regulator that works as a splicing factor as part of the spliceosome, and as a transcriptional activator by forming transcriptional regulator complex. SKIP interacts with ELF7, a core component of the Paf1 complex (Paf1c), to form the SKIP-Paf1c to represses the floral transition in Arabidopsis. SKIP interacts with MAC3A and MAC3B in the spliceosome, and that they are required for the proper functioning of the circadian clock and abiotic stress response in Arabidopsis. However, neither MAC3A nor MAC3B interacts physically and genetically with ELF7. The SKIP-MAC3A/B complex mediates circadian clock function and abiotic stress responses by controlling the alternative splicing of pre-mRNAs encoded by clock- and stress tolerance-related genes. The SKIP-Paf1c regulates the floral transition by activating FLC transcription. Therefore, SKIP regulates development and environmental fitness by forming two distinct complexes that regulate gene expression transcriptionally and post-transcriptionally, respectively, in Arabidopsis.