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Sensitive Monitoring of Fluoroquinolones in Milk and Honey Using Multiple Monolithic Fiber Solid-Phase Microextraction Coupled to Liquid Chromatography Tandem Mass Spectrometry

发布时间:2017-04-05
作 者:Chen, L; Huang, XJ

影响因子:2.959

刊物名称:JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

出版年份:2016

卷:64  页码:  8684−8693

In the present study, a new multiple monolithic fiber solid-phase microextraction (MMF-SPME) based on poly(apronal co-divinylbenzene/ethylenedimethacrylate) monolith (APDE) was synthesized. The effect of the preparation parameters of APED on extraction efficiency was studied thoroughly. The combination of APDE/MMF-SPME with high-performance liquid chromatography tandem mass spectrometry detection (HPLC/MS-MS) was developed for sensitive monitoring of ultratrace fluoroquinolones (FQs) in foodstuffs, including milk and honey samples. Under the optimized experimental conditions, the limits of detection (S/N = 3) for the targeted FQs ranged from 0.0019 to 0.018 μg/kg in milk and 0.0010 to 0.0028 μg/kg in honey. The relative standard deviations (RSDs) for method reproducibility were less than 9% in all samples. The established method was successfully applied for the monitoring of FQs residues in milk and honey samples with the recoveries between 74.5% and 116% (RSDs were in the range 0.9-9.5%). In comparison to previous methods, the developed APDE/MMF-SPME-HPLC/MS-MS showed some merits, including satisfactory sensitivity, simplicity, high cost-effectiveness, and low consumption of organic solvent.
Fig. 1. Reaction sketch of the poly(AP-co-DB/ED) monolith.



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