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Revealing the complex effects of salinity on copper toxicity in an estuarine clam Potamocorbula laevis with a toxicokinetic-toxicodynamic model

发布时间:2018-07-24
作 者:Chen, WQ; Wang, WX; Tan, QG
影响因子:5.099
刊物名称: ENVIRONMENTAL POLLUTION
出版年份:2017
卷:222   页码: 323-330

The effects of salinity on metal toxicity are complex: not only affecting metal bioaccumulation, but also

altering the physiology and sensitivity of organisms. In this study, we used a toxicokinetic-toxicodynamic

(TK-TD) model to separate and quantify the dual effects of salinity on copper (Cu) toxicity in a euryhaline

clam Potamocorbula laevis. The toxicokinetics of Cu was determined using the stable isotope 65Cu as a

tracer at concentrations (10e500 mg L_1) realistic to contaminated environments and at salinities ranging

from 5 to 30. At low Cu concentrations (ca. 10 mg L_1), Cu bioaccumulation decreased monotonically with

salinity, and the uptake rate constant (ku, 0.546 L g_1 h_1 to 0.213 L g_1 h_1) fitted well with an empirical

equation, ku ? 1/(1.35 t 0.116$Salinity), by treating salinity as a pseudo-competitor. The median lethal

concentrations (LC50s) of Cu were 269, 224, and 192 mg L_1 at salinity 5, 15, and 30, respectively. At high

Cu concentrations (ca. 500 mg L_1), elevating salinity were much less effective in decreasing Cu bioaccumulation;

whereas Cu toxicity increased with salinity. The increased toxicity could be explained by

the increases in Cu killing rates (kks), which were estimated to be 0.44e2.08 mg mg_1 h_1 and were

presumably due to the osmotic stress caused by the deviation from the optimal salinity of the clams. The

other toxicodynamic parameter, internal threshold concentration (CIT), ranged from 79 to 133 mg_1 g_1

and showed no clear trend with salinity.


Fig. 17. The survivorship of the clam P. leavis during the 72-h exposure to 500 mg L1 Cu

(nominal) at salinities ranging from 5 to 30. The dots are the observed survivorship and

the error bars are standard deviation (n ¼ 3); and the dashed lines are the model fits.

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