Xiaojia Huang,Linli Chen,Meng Chen,Dongxing

Yuan,Shuyu Nong.Journal of Separation Science, 2013. 36: 907-915.

In the present study, a convenient and sensitive method for

determination of six penicillinantibiotics (amoxicillin, ampicillin, penicillin

G, oxacillin, cloxacillin, and dicloxacillin)in milk and honey samples was

developed. Milk and honey samples were diluted withwater, then directly treated

by stir bar sorptive extraction based on poly

(vinylimidazoledivinylbenzene)monolithic material as coating. The analytes were

analyzed by LC/ESIMS/MS. Several extraction parameters including extraction and

desorption time, pH value,and ionic strength in sample matrix were investigated

in detail. Under the optimized extractionconditions, the calculated detection

limits for the target compounds were as lowas 0.23–2.66 ng/kg in milk and

0.18–1.42 ng/kg in honey, respectively. Good linearity wasobtained for analytes

with the correlation coefficients (R2) above 0.997. Excellent

methodreproducibility was achieved in terms of intraday and interday

precisions, indicated by theRSDs of <5 .0 and <10.0%, respectively.

Finally, the proposed method was successfullyapplied to the determination of

penicillin antibiotics residues in different milk and honeysamples.

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