Ting-Wu Liu, Li Niu, Bin Fu, Juan Chen, Fei-Hua Wu, Juan Chen, Wen-Hua Wang, Wen-Jun Hu, Jun-Xian He, and Hai-Lei Zheng.Genome,2013. 56: 49-60.

Acid rain, as a worldwide environmental issue, can cause serious damage to plants. In this study, we provided the firstcase study on the systematic responses of arabidopsis (Arabidopsis thaliana (L.) Heynh.) to simulated acid rain (SiAR) by transcriptomeapproach. Transcriptomic analysis revealed that the expression of a set of genes related to primary metabolisms, includingnitrogen, sulfur, amino acid, photosynthesis, and reactive oxygen species metabolism, were altered under SiAR. In addition,transport and signal transduction related pathways, especially calcium-related signaling pathways, were found to play importantroles in the response of arabidopsis to SiAR stress. Further, we compared our data set with previously published data sets onarabidopsis transcriptome subjected to various stresses, including wound, salt, light, heavy metal, karrikin, temperature,osmosis, etc. The results showed that many genes were overlapped in several stresses, suggesting that plant response to SiAR isa complex process, which may require the participation of multiple defense-signaling pathways. The results of this study willhelp us gain further insights into the response mechanisms of plants to acid rain stress.