Wei-Ming Chai, Xuan Liu, Yong-Hua Hu, Hui-Ling

Feng, Yu-Long Jia, Yun-Ji Guo,Han-Tao Zhou, Qing-Xi Chen.PInternational Journal of

Biological Macromolecules, 2013.57:

151-155.

The inhibitory kinetics of furfuryl alcohol, furfural and furoic

acid on mushroom tyrosinase have beeninvestigated. The results showed that

these furan compounds were reversible inhibitors of the enzyme.Furthermore,

furfuryl alcohol and furfural were found to be mixed-type inhibitors while

furoic acid isuncompetitive inhibitor. The inhibition constants have been

confirmed and the order of the inhibitingability was furfural > furoic acid

> furfuryl alcohol. They indicate that the functional groups on the

furanring play a crucial role in the inhibition on the enzyme. In addition, it

was also found that these furancompounds could inhibit the proliferation of Salmonella

bacteria and Bacillus subtilis to different extents.The minimum inhibitory

concentration (MIC) values of furfuryl alcohol, furfural and furoic acid

againstB. subtilis and S. bacteria were 0.115, 0.027, 0.015 and 0.115, 0.029,

0.009 _M, respectively. The minimumbactericidal concentration (MBC) values of

that were 0.115, 0.027, 0.015 and 0.231, 0.121, 0.030 _M,respectively.

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